GLP-1 medications are a class of drugs specifically aimed at aiding weight management and are used in the treatment of obesity and type-2 diabetes.

They are named after the natural hormone they mimic, Glucagon-like Peptide-1 (GLP-1), which your body produces and is secreted by intestinal enteroendocrine L-cells and certain neurons in the brainstem upon food intake.

Semaglutide and tirzepatide are both effective medications for helping people lose weight. Both work by mimicking hormones your body normally makes after you eat—semaglutide mimics one hormone and tirzepatide mimics two hormones.

Semaglutide works solely as a GLP-1 receptor agonist, which essentially tells your brain that you're full. By mimicking the action of GLP-1, it helps regulate appetite and blood sugar levels, while also slowing gastric emptying, leading to a feeling of fullness.

Tirzepatide combines the actions of GLP-1 and GIP receptor agonists. This dual action sets tirzepatide apart, offering the potential for even greater reductions in blood sugar levels and weight loss compared to semaglutide. Tirzepatide has also demonstrated a lower risk of hypoglycemia, making it an attractive option for individuals who are prone to low blood sugar episodes.

Compounded medications can be used when FDA-approved drugs are in short supply. Compounded GLP-1 medications are not FDA-approved, while name-brand GLP-1 medications are. Compounded drugs are required to exclusively use ingredients from FDA-licensed facilities, and test sterile compounds for potency, sterility, and purity. Thrive exclusively works with US based 503A and 503B pharmacies.

While compounded drugs are legal, they do not undergo pre-market approval from the FDA as they are not made in large batches for the public, compounds are made based on specific orders from a medical professional. Because of that the dose, route of administration, and efficacy may differ from commercially available, brand-name, drugs.

Compounded GLP-1s generally come in vials, which require patients to measure out the correct dose with a syringe. While name-brand GLP-1s typically come in pre-measured auto-injectors, which can be easier to use. Another difference to consider is that compounded medications can be more affordable than name-brand drugs. 

GLP-1 medications work by mimicking the natural GLP-1 hormone, which is released by your intestines after you eat. This hormone plays a critical role in signaling to your brain that you are full, helping to control your appetite. By leveraging this mechanism, GLP-1 medications make you feel fuller sooner and longer after eating, which can lead to reduced calorie intake and subsequent weight loss. GLP-1s are also valuable for improving blood sugar levels, offering a dual benefit for individuals with obesity and type 2 diabetes.

When using GLP-1 medications, you might experience several benefits including a notable reduction in body weight, decreased appetite, improved blood sugar levels, and even some cardiovascular advantages such as a reduced risk of heart attack and stroke in certain individuals.

Yes, while GLP-1 medications can be highly beneficial, they may come with potential side effects. Common side effects include gastrointestinal issues such as nausea and vomiting, a possible increased risk of pancreatitis, low blood sugar levels especially when combined with other medications, and reactions at the injection site. It is also important to note that these medications are not recommended for individuals with certain medical histories related to thyroid cancer.

Deciding if GLP-1 medications are suitable for you involves an evaluation with a medical provider. They will consider your individual health status, weight loss goals, and any potential risks to determine if this treatment aligns with your needs and health.